Biological activity of tri-calciumphosphate/hydroxyl-apatite granules mixed with impacted morsellized bone graft. A study in rabbits
✍ Scribed by J. J. C. Arts; L. H. B. Walschot; N. Verdonschot; B. W. Schreurs; P. Buma
- Publisher
- John Wiley and Sons
- Year
- 2007
- Tongue
- English
- Weight
- 517 KB
- Volume
- 81B
- Category
- Article
- ISSN
- 1552-4973
No coin nor oath required. For personal study only.
✦ Synopsis
Abstract
Reconstruction of bone defects with impacted morsellized cancellous bone grafts (MCB) is a popular method. Because of a shortage of human bone, mixing with biomaterials may be attractive. Ceramics may be used as bone graft extenders. In this study, various volume mixtures of biphasic tri‐calciumphosphate/hydroxyl‐apatite (TCP‐HA) granules (1.5–2 mm) with MCB were examined in a non‐loaded defect model in rabbits. Direct post‐operatively, many 10–150 μm TCP‐HA particles were present due to impaction. Irrespective to the group, after 8 weeks, virtually all MCB was resorbed and most TCP‐HA granules were osseous‐integrated with newly formed bone. The cross‐sectional areas of TCP‐HA after 8 weeks was generally smaller compared with direct post‐operatively and the number of small 10–150 μm TCP‐HA particles seemed reduced. Macrophages and giant cells were sparse after 8 weeks. In conclusion, the osteoconductivity of various mixtures of MCB and TCP‐HA granules is not dependent on the ratio of TCP‐HA over MCB. The reduced number of the 10–150 μm TCP‐HA particles after 8 weeks, may suggest that a cellular mediated resorption process of TCP‐HA granules took place. Based on these favorable biological findings subsequent in‐vivo experiments are warranted in load‐bearing conditions to investigate whether these findings hold for joint reconstruction purposes. © 2006 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 2006