Biological activity of pentobarbital metabolites

✍ Scribed by H. D. Christensen; L. Barnett; F. I. Carroll

• Book ID: 102407219
• Publisher: John Wiley and Sons
• Year: 1973
• Tongue: English
• Weight: 191 KB
• Volume: 62
• Category: Article
• ISSN: 0022-3549
• DOI: 10.1002/jps.2600621036

✦ Synopsis

40 50 60 70 80 90 100 DAYS Figure 2-Mole percent decomposition of aspirin with time in a polyethylene glyc01 base containing I % citric acid.

The effect of 10% tartaric acid on aspirin decomposition in this base was studied for B limited period, and the results were similar to those obtained with 5 and 10% citric acid for a comparable time. The percent decomposition at 26" was slightly lower with tartaric acid, but little difference was noted between these similar acids at 45 and 4".

Conclusions

Certain substances can be added to a polyethylene glycol-type aspirin suppository mixture without appreciably changing its properties. Of the several additives studied, citric and tartaric acids inhibited decomposition. A 5 % concentration of citric acid appeared to be the optimum concentration necessary to hinder decomposition. The importance of refrigeration at 4" on decomposition of aspirin in polyethylene glycol was evident.