𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Biological activities of laminin

✍ Scribed by Hynda K. Kleinman; Frances B. Cannon; Gordon W. Laurie; John R. Hassell; Monique Aumailley; Victor P. Terranova; George R. Martin; Monique DuBois-Dalcq

Book ID
102878545
Publisher
John Wiley and Sons
Year
1985
Tongue
English
Weight
515 KB
Volume
27
Category
Article
ISSN
0730-2312

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✦ Synopsis

Laminin is a multifunctional protein with diverse biological activities. Like fibronectin, it can influence cell adhesion, growth, morphology, differentiation, migration, and agglutination as well as the assembly of the extracellular matrix. Laminin primarily affects cells of epithelial origin, and the response varies depending on the cell. Because most differentiated cells are difficult to maintain in culture, laminin may be an important supplement in studies on cell differentiation in vitro.

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Regulation of biological activity of laminin-5 by proteolytic processing of Ξ³2 chain
✍ Takashi Ogawa; Yoshiaki Tsubota; Masato Maeda; Yoshinobu Kariya; Kaoru Miyazaki πŸ“‚ Article πŸ“… 2004 πŸ› John Wiley and Sons 🌐 English βš– 494 KB

## Abstract Laminin‐5 (LN5), which regulates both cell adhesion and cell migration, undergoes specific extracellular proteolytic processing at an amino‐terminal region of the Ξ³2 chain as well as at a carboxyl‐terminal region of the Ξ±3 chain. To clarify the biological effect of the Ξ³2 chain processi