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Biological Activities of Avarol Derivatives, 1. Amino Derivatives

✍ Scribed by Cozzolino, R.; De Giulio, A.; De Rosa, S.; Strazzullo, G.; Gašič, M. J.; Sladić, D.; Zlatović, M.

Book ID
120938916
Publisher
American Chemical Society
Year
1990
Tongue
English
Weight
250 KB
Volume
53
Category
Article
ISSN
0163-3864

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✍ Wei Guo; Zhenyuan Miao; Chunquan Sheng; Jianzhong Yao; Wenfeng Liu; Lingjian Zhu 📂 Article 📅 2011 🏛 John Wiley and Sons 🌐 English ⚖ 430 KB 👁 1 views

## Abstract Six 9‐(heteroarylmethylidene)amino derivatives, **2a**–**2f**, of homocamptothecin were synthesized for the first time by total synthesis in 22 steps and biologically evaluated as inhibitors of topoisomerase I. Moreover, the antitumor activities of **2a**–**2f** against three human tumo