Biologic basis and evolving role of aromatase inhibitors in the management of invasive carcinoma of the breast
β Scribed by Henry M. Kuerer; Aman U. Buzdar; S. Eva Singletary
- Publisher
- John Wiley and Sons
- Year
- 2001
- Tongue
- English
- Weight
- 369 KB
- Volume
- 77
- Category
- Article
- ISSN
- 0022-4790
- DOI
- 10.1002/jso.1085
No coin nor oath required. For personal study only.
π SIMILAR VOLUMES
## Abstract ## BACKGROUND The authors examined the published evidence on the use of aromatase inhibitors (AIs) in the adjuvant setting in postmenopausal, hormone receptorβpositive patients, and they provide recommendations for clinical management in 3 different situations: newly diagnosed women, w
Estrogens are the major hormones supporting the growth of human breast cancer. Aromatization of androgen precursors in peripheral tissues, including the breast cancer itself, is the major source of estrogens in postmenopausal women. Therefore, inhibition of the aromatase enzyme offers an effective m