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Biologic and immunologic effects of preoperative trastuzumab for ductal carcinoma in situ of the breast

โœ Scribed by Henry M. Kuerer; Aman U. Buzdar; Elizabeth A. Mittendorf; Francisco J. Esteva; Anthony Lucci; Luis M. Vence; Laszlo Radvanyi; Funda Meric-Bernstam; Kelly K. Hunt; William Fraser Symmans


Publisher
John Wiley and Sons
Year
2010
Tongue
English
Weight
308 KB
Volume
117
Category
Article
ISSN
0008-543X

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Ductal carcinoma in situ of the breast
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Background. Ductal carcinoma in situ (DCIS) of the male breast is an uncommon disease, accounting for approximately 7% of all male breast carcinomas. Compared with invasive carcinomas of the breast, the prognosis associated with DCIS in men is excellent; however, clinical features, pathology, and tr

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Ductal carcinoma in situ (DCIS) now accounts for 20-30% of all newly diagnosed breast cancers in centers which use mammographic surveillance as a standard part of the examination. The majority of these DCIS lesions, at least in the United States, are of very limited size, with mean estimated extents

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โœ Melvin J. Silverstein; Michael D. Lagios; Pamela H. Craig; James R. Waisman; Ber ๐Ÿ“‚ Article ๐Ÿ“… 1996 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 663 KB

## BACKGROUND. There is controversy and confusion regarding therapy for patients with ductal carcinoma in situ (DCIS) of the breast. The Van Nuys Prognostic Index (VNPI) was developed to aid in the complex treatment selection process.

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Ductal carcinoma in situ (DCIS) was a relatively uncommon disease process when we relied on palpation to detect breast lesions. With the advent of more widespread mammography screenings, the surgeon is faced with a welcome opportunity to prevent cancer by dealing with a precursor lesion. Discovering

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## Background: More than 50% of breast ductal carcinomas in situ (dcis) contain significant histologic necrosis, an important prognostic factor for determining recurrence and progression to invasive breast cancer. we have examined whether the mechanism of this spontaneous cell death might be apopto