Biologic activity of the novel small molecule STAT3 inhibitor LLL12 against canine osteosarcoma cell lines

The novel HSP90 inhibitor STA-1474 exhib

The novel HSP90 inhibitor STA-1474 exhibits biologic activity against osteosarcoma cell lines

✍ Jennifer K. McCleese; Misty D. Bear; Stacey L. Fossey; Robert M. Mihalek; Kevin 📂 Article 📅 2009 🏛 John Wiley and Sons 🌐 French ⚖ 568 KB

## Abstract Osteosarcoma (OSA), the most common malignant bone tumor in dogs and children, exhibits a similar clinical presentation and molecular biology in both species. Unfortunately, 30–40% of children and 90% of dogs still die of disease despite aggressive therapy. The purpose of this study was