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Biologic activity of dihydroxylated 19-nor-(pre)vitamin D3

✍ Scribed by Roger Bouillon; Luis A. Sarandeses; Katrien Allewaert; Jie Zhao; Luis J. Mascareñas; Antonio Mouriño; Sara Vrielynck; Pierre De Clercq; Maurits Vandewalle

Book ID
112119118
Publisher
American Society for Bone and Mineral Research
Year
2009
Tongue
English
Weight
499 KB
Volume
8
Category
Article
ISSN
0884-0431

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✍ Kato L. Perlman; Rafal R. Sicinski; Heinrich K. Schnoes; Hector F. DeLuca 📂 Article 📅 1990 🏛 Elsevier Science 🌐 French ⚖ 89 KB

l~,25-Dihydroxy-19-nor-vitamin D 3 has been synthesized via oxidative degradation of the l~-hydroxycylcovitamin intermediate. Preliminary studies indicate that the new analog induces the differentiation of human leukemia HL-60 cells, with little or no calcemic activity. The hormone, l~,25-dihydrox