Mechanism of cytotoxic activity of 5′-de
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R. Douglas Armstrong; Kevin M. Connolly; Alan M. Kaplan; Ed Cadman
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Article
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1983
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Springer
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English
⚖ 418 KB
The purpose of these studies was to characterize the effect of the new fluoropyrimidine nucleoside 5'-deoxy-5-fluorouridine (5'dFUrd) on macromolecular processes in correlation with its cytotoxicity in Ehrlich ascites tumor cells. Following a 2-h exposure, 5'-dFUrd exhibited an LD50 (as determined b