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Biologic Activity of 5′-Deoxy-5-fluorouridine by Rectal Administration

✍ Scribed by Steven L. Bramer; Lena C. Gunnarsson; J. Lai-Sim Au


Book ID
114421095
Publisher
Springer US
Year
1989
Tongue
English
Weight
857 KB
Volume
06
Category
Article
ISSN
0724-8741

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The purpose of these studies was to characterize the effect of the new fluoropyrimidine nucleoside 5'-deoxy-5-fluorouridine (5'dFUrd) on macromolecular processes in correlation with its cytotoxicity in Ehrlich ascites tumor cells. Following a 2-h exposure, 5'-dFUrd exhibited an LD50 (as determined b