Bioinspired Colorimetric Detection of Calcium(II) Ions in Serum Using Calsequestrin-Functionalized Gold Nanoparticles

✍ Scribed by Sunghyun Kim; Jeong Won Park; Dongkyu Kim; Daejin Kim; In-Hyun Lee; Sangyong Jon

• Publisher: John Wiley and Sons
• Year: 2009
• Tongue: English
• Weight: 486 KB
• Volume: 48
• Category: Article
• ISSN: 0044-8249
• DOI: 10.1002/anie.200900071

✦ Synopsis

Abstract

Seeing is sensing: Calsequestrin (CSQ) functionalized gold nanoparticles undergo calcium‐dependent CSQ polymerization, which results in a clear color change (see picture) together with precipitation. The sensing system is specific for Ca^2+^ ions and the differences between normal and disease‐associated abnormal (hypercalcemia) Ca^2+^ ion levels in serum can be distinguished with the naked eye.magnified image