Bioinspired Block Copolymers: Translating Structural Features from Proteins to Synthetic Polymers
✍ Scribed by André Laschewsky; Jean-Noël Marsat; Katja Skrabania; Hans von Berlepsch; Christoph Böttcher
- Publisher
- John Wiley and Sons
- Year
- 2010
- Tongue
- English
- Weight
- 470 KB
- Volume
- 211
- Category
- Article
- ISSN
- 1022-1352
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✦ Synopsis
Abstract
In order to mimic a key functional feature of the transport protein serum albumin that disposes of several different simultaneous binding sites, new ternary linear block copolymers were synthesized. The block copolymers are made of one non‐ionic hydrophilic block based on derivatives of poly(oligoethyleneglycol), and of two mutually immiscible hydrophobic poly(acrylate) blocks, based on hydrocarbon and fluorocarbon esters of acrylic acid, respectively. The polymers self‐organize in aqueous solution to micellar aggregates, which undergo microphase separation within the hydrophobic micellar core. The different aggregate structures were imaged by transmission electron cryo‐microscopy (cryo‐TEM). Depending on the detailed polymer architecture, either core‐shell‐corona micelles, or micelles with a true multicompartment structure were formed, that are capable of selective solubilization.
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