Bioinformatics for High Throughput Sequencing Volume 35D1 || Differential Expression for RNA Sequencing (RNA-Seq) Data: Mapping, Summarization, Statistical Analysis, and Experimental Design

✍ Scribed by Rodríguez-Ezpeleta, Naiara; Hackenberg, Michael; Aransay, Ana M.

• Book ID: 111980004
• Publisher: Springer New York
• Year: 2011
• Tongue: English
• Weight: 552 KB
• Edition: 2012
• Category: Article
• ISBN: 1461407826
• DOI: 10.1007/978-1-4614-0782-9_10

✦ Synopsis

Next generation sequencing is revolutionizing molecular biology. Owing to this new technology it is now possible to carry out a panoply of experiments at an unprecedented low cost and high speed. These go from sequencing whole genomes, transcriptomes and small non-coding RNAs to description of methylated regions, identification protein – DNA interaction sites and detection of structural variation. The generation of gigabases of sequence information for each of this huge bandwidth of applications in just a few days makes the development of bioinformatics applications for next generation sequencing data analysis as urgent as challenging.