✦ LIBER ✦

Biogenic amines and some metals in brain of cadmium-exposed diabetic rats

✍ Scribed by Satya V. Chandra; Kiran Kalia; Tahir Hussain

Publisher: John Wiley and Sons
Year: 1985
Tongue: English
Weight: 317 KB
Volume: 5
Category: Article
ISSN: 0260-437X
DOI: 10.1002/jat.2550050608

No coin nor oath required. For personal study only.

✦ Synopsis

Diabetic rats (alloxan diabetes) were exposed to cadmium (2 mg kg-' i.p.) daily for 21 days to investigate the levels of blood glucose, biogenic amines and iron, copper, zinc and cadmium in the brain. Cadmium exposure to diabetic rats produced a significant exacerbation i n the hyperglycemic effect and accumulation of cadmium in the blood compared with that observed after diabetes or cadmium exposure alone. The elevation in the levels of brain dopamine and 5-hydroxytryptamine were also more pronounced in cadmiumexposed diabetic rats compared with either cadmium exposure or diabetes alone. Cadmium exposure to diabetic rats also produced significant changes in the concentrations of copper in the blood. These results indicated enhanced cadmium toxicity in diabetic rats.

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