✦ LIBER ✦

Biogenesis of mitochondria 40

✍ Scribed by M. K. Trembath; B. C. Monk; G. M. Kellerman; A. W. Linnane

Book ID: 104692911
Publisher: Springer
Year: 1975
Tongue: English
Weight: 358 KB
Volume: 140
Category: Article
ISSN: 1617-4615
DOI: 10.1007/bf00267323

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✦ Synopsis

A mutant has been isolated which carries a nuclear mutation capable of suppressing certain aspects of the phenotype imposed by a specific mitochondrial mutation. The mitochondrial mutation [tso-r] confers cold sensitivity to growth on nonfermentable substrates and resistance to oligomycin. When both the mitochondrial and nuclear mutations are present in the same cell the cell is phenotypically cold resistant but retains a high level of oligomycin resistance. The extent of cold sensitivity suppression is dependent upon other unspecified nuclear genes. The molecular basis for the suppression may involve interactions between cytoplasmic and mitochondrial ATPase.

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