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Biogenesis of MiRNA-195 and its role in biogenesis, the cell cycle, and apoptosis

✍ Scribed by Jun-Feng He; Yu-Mei Luo; Xin-Hong Wan; Deqian Jiang

Publisher
John Wiley and Sons
Year
2011
Tongue
English
Weight
137 KB
Volume
25
Category
Article
ISSN
1095-6670

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✦ Synopsis

Abstract

microRNA‐195(miR‐195) is an important member of the micro‐15/16/195/424/497 family, and which is activated in multiple diseases, such as cancers, heart failure, and schizophrenia. Mir‐195 regulates a plethora of target proteins, which are involved in the cell cycle, apoptosis, proliferation. WEE1, CDK6, and Bcl‐2 are confirmed target genes of miR‐195 that are involved in miR‐195‐mediated cell‐cycle and apoptosis effects. However, the mechanism of miR‐195 action is not completely understood. This review summarizes recent the research progress regarding the roles of miR‐195 in the cell cycle and in apoptosis. © 2011 Wiley Periodicals, Inc. J Biochem Mol Toxicol 25:404–408 2011; View this article online at wileyonlinelibrary.com. DOI 10.1002/jbt.20396

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