Biofunctionalization of Polyelectrolyte Microcapsules with Biotinylated Polyethylene Glycol-Grafted Liposomes
✍ Scribed by Jie Gao; Uta Reibetanz; Subbu Venkatraman; Björn Neu
- Book ID
- 102934914
- Publisher
- John Wiley and Sons
- Year
- 2011
- Tongue
- English
- Weight
- 935 KB
- Volume
- 11
- Category
- Article
- ISSN
- 1616-5187
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✦ Synopsis
Abstract
Hollow polyelectrolyte microcapsules (PEMC) are prepared using layer‐by‐layer self‐assembly of polyelectrolytes on melamine formaldehyde templates, followed by template dissolution, and subsequent coating with biotinylated polyethylene glycol‐grafted liposomes. These potential site‐specific carrier systems show a high specificity for NeutrAvidin binding and a strong resistance against unspecific protein binding. It is concluded that this design with NeutrAvidin as the outermost layer of such capsules provides an ideal platform for the biofunctionalization of PEMC as drug delivery systems or as artificial cell‐like structures for biomimetic studies. magnified image