✦ LIBER ✦

BioEssays 12/2011

Book ID: 101705882
Publisher: John Wiley and Sons
Year: 2011
Tongue: English
Weight: 199 KB
Volume: 33
Category: Article
ISSN: 0265-9247
DOI: 10.1002/bies.201190067

No coin nor oath required. For personal study only.

✦ Synopsis

Invertebrate models of spinal muscular atrophy (SMA). On pages 956‐965 Stuart Grice et al. highlight insights made into SMA using Drosophila melanogaster and Caenorhabditis elegans. With their tractable nervous systems, genetic amenability, and large reproductive capacities, the invertebrate models have provided a valuable contribution to understanding the cellular function of the survival motor neuron (SMN) protein, to unravelling the underlying genetic pathways pertinent to SMA, and to identifying potential therapeutics. The cover image shows a Drosophila larval brain lobe stained for SMN (green) with enrichments in the post embryonic neuroblasts (red; top left), a Drosophila larva expressing red fl uorescent protein in the nervous system (middle), and an adult C. elegans smn‐1 point mutant expressing green fl uorescent protein within the nervous system (bottom right).

Cover by S. J. Grice and J. N. Sleigh

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