𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Bioequivalence Trials with the Incomplete 3 × 3 Crossover Design

✍ Scribed by Nam-Kyoo Lim; Sang-Gue Park; Ed Stanek

Book ID
101711310
Publisher
John Wiley and Sons
Year
2005
Tongue
English
Weight
107 KB
Volume
47
Category
Article
ISSN
0323-3847

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✦ Synopsis

In bioequivalence trials, one often considers two or more generic products with the original one. The 3 x 3 crossover design can be adopted to evaluate the two generic candidates with a brand name drug, rather than conducting two separate 2 x 2 crossover trials. Dropouts, however, are more likely to occur due to various administrative reasons when we consider a higher order crossover design. A modified method, which was originally given by Chow and Shao (1997), is extended to compare two generic products with a reference in the incomplete 3 x 3 crossover design. A simulation study and discussion are also presented.

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