𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Bioequivalence of two pharmaceutical forms of diltiazem

✍ Scribed by Modesto Rubio; Mónica I. Masana; Enrique Garcilazo; Antonio R. de Los Santos; Guillermo di Girolamo

Publisher
John Wiley and Sons
Year
1990
Tongue
English
Weight
287 KB
Volume
11
Category
Article
ISSN
0142-2782

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✦ Synopsis

Diltiazem, a calcium-channel blocking agent, has been shown to be a potent coronary vasodilator used in the treatment of ischaemic heart disease. The present study was conducted to compare the bioavailability of regular 60 mg tablets administered every 6 h with sustained release capsules of 120 mg administered every 12 h. High-performance liquid chromatographic analysis was carried out for determination of diltiazem and one of its metabolites desacetildiltiazem in six male patients. The relative bioavailability of this sustained-release pharmaceutical form did not show any significant difference with that of tablets.

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