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Bioenergetic modulation overcomes glucocorticoid resistance in T-lineage acute lymphoblastic leukaemia

โœ Scribed by Samuels, Amy L.; Heng, Jasmin Y.; Beesley, Alex H.; Kees, Ursula R.


Book ID
121721676
Publisher
John Wiley and Sons
Year
2014
Tongue
English
Weight
522 KB
Volume
165
Category
Article
ISSN
0007-1048

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Glucocorticoids (GCs) are common components of many chemotherapeutic regimens for lymphoid malignancies including acute lymphoblastic leukemia (ALL). The BCL-2 family has an essential role in regulating GC-induced cell death. Here we show that downregulation of antiapoptotic BCL-2 family proteins, e