The blood kinetics and tumour localization of a conjugate of methotrexate (MTX) and MAb 791T136 were examined i n nude mice with human tumour xenografts. The antibod moiety of the conjugate was detected by labelling with l2J and the drug moiety was assayed using a radioimmunoassay for methotrexate.
Biodistribution and tumour localization of radiolabelled monoclonal antibody during continuous infusion in nude mice and with human tumour xenografts
โ Scribed by Pimm, M.V.; Clegg, J.A.; Baldwin, R.W.
- Book ID
- 122956888
- Publisher
- Elsevier Science
- Year
- 1987
- Weight
- 666 KB
- Volume
- 23
- Category
- Article
- ISSN
- 0277-5379
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