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Biodistribution and safety studies of hDel-1 plasmid-based gene therapy in mouse and rabbit models

✍ Scribed by A. Quezada; M. French; J. Perrard; R. Durland; M. Coleman; J. Larson; R. Ponce

Book ID
111769041
Publisher
Pharmaceutical Press
Year
2004
Tongue
English
Weight
232 KB
Volume
56
Category
Article
ISSN
2042-7158

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## Abstract ## Background A model for __in vivo__ gene therapy based on electroporation of human growth hormone (hGH)‐coding naked DNA in the muscle of dwarf (lit/lit) and immunodeficient dwarf (lit/scid) mice is described. ## Methods A plasmid containing the ubiquitin C promoter and the genomic