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Biodistribution and Pharmacokinetic Studies of Bone-Targeting N -(2-Hydroxypropyl)methacrylamide Copolymer−Alendronate Conjugates

✍ Scribed by Pan, Huaizhong; Sima, Monika; Kopečková, Pavla; Wu, Kuangshi; Gao, Songqi; Liu, Jihua; Wang, Dong; Miller, Scott C.; Kopeček, Jindřich


Book ID
120249367
Publisher
American Chemical Society
Year
2008
Tongue
English
Weight
148 KB
Volume
5
Category
Article
ISSN
1543-8384

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## Abstract Bone‐targeting __N__‐(2‐hydroxypropyl)methacrylamide (HPMA) copolymer‐PGE~1~ conjugates, containing cathepsin K sensitive spacers, were incubated with induced osteoclasts and osteoblasts, their precursors, and control non‐skeletal cells. The release of PGE~1~ was monitored by an HPLC as