Biodistribution and in vivo efficacy of genetically modified human mesenchymal stem cells systemically transplanted into a mouse bone fracture model

Glial cell line-derived neurotrophic fac

Glial cell line-derived neurotrophic factor–secreting genetically modified human bone marrow-derived mesenchymal stem cells promote recovery in a rat model of Parkinson's disease

✍ Aleksandra Glavaski-Joksimovic; Tamas Virag; Thomas A. Mangatu; Michael McGrogan 📂 Article 📅 2010 🏛 John Wiley and Sons 🌐 English ⚖ 456 KB 👁 1 views

## Abstract Parkinson's disease (PD) is a neurodegenerative disease characterized by progressive degeneration of nigrostriatal dopaminergic (DA) neurons. The therapeutic potential of glial cell line‐derived neurotrophic factor (GDNF), the most potent neurotrophic factor for DA neurons, has been dem