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Biodegradation of copoly(n-hydroxypropyl-d,l-glutamine) in vitro

โœ Scribed by Toshio Hayashi; Eiji Nakanishi; Yasuko Iizuka; Masanao Oya; Makoto Iwatsuki

Publisher
Elsevier Science
Year
1994
Tongue
English
Weight
372 KB
Volume
30
Category
Article
ISSN
0014-3057

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โœฆ Synopsis

Random copolypeptides (PHPDLG) consisting of N-hydroxypropyl-D-glutamine (HPDG) and N-hydroxypropyl-L-glutamine (HPLG) covering the whole range of D,L-copolymer composition were prepared by carrying out aminolysis reactions with 3-amino-l-propanol (P) on starting random copolymers consisting of 7-benzyl-o-glutamate and 7-benzyl-L-glutamate (PBDLG). The effects of copolymer composition and sequential distributions on the rate of hydrolysis by papain in a pseudo-extracellular fluid (PECF) at pH 7.4 and 37.0ยฐC were studied to simulate in vivo polymer degradation. Degradation data for these samples followed the Michaelis Menten rate law, being of the first order to the enzyme concentration. It was shown that the rate of degradation by papain was controlled by the comonomer composition as well as sequential distributions of comonomers in the copolymer chains.

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