✦ LIBER ✦

Biodegradation behavior of various calcium phosphate materials in bone tissue

✍ Scribed by Klein, C. P. A. T. ;Driessen, A. A. ;de Groot, K. ;van den Hooff, A.

Publisher: John Wiley and Sons
Year: 1983
Tongue: English
Weight: 916 KB
Volume: 17
Category: Article
ISSN: 0021-9304
DOI: 10.1002/jbm.820170505

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

In order to study the biodegradation behavior of calcium phosphate materials, cylinders of standard size were implanted in the tibiae of rabbits. Material parameters were stoichiometry (hydroxyapatite with a Ca/P ratio of 1.67 versus tricalcium phosphate with a Ca/P ratio of 1.50), crystallographic structure (apatite versus β‐whitlockite), microporosity, and macroporosity. The extent of biodegradation was evaluated by radiography, light and fluorescence microscopy, microradiography, and porosity measurements. All calcium phosphate materials were biocompatible in bone tissue. Hydroxyapatite ceramics had a higher osteogenic potential than β‐whitlockite materials. Depending on their porosities, sintered tricalciumphosphate (β‐whitlockite) materials were more or less biodegradable, in contrast to sintered hydroxyapatite materials, which showed no detectable resorption over a period of 9 months of implantation.

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