Biodegradation and biocompatibility of a guided tissue regeneration barrier membrane formed from a liquid polymer material
✍ Scribed by Coonts, B. A. ;Whitman, S. L. ;O'Donnell, M. ;Polson, A. M. ;Bogle, G. ;Garrett, S. ;Swanbom, D. D. ;Fulfs, J. C. ;Rodgers, P. W. ;Southard, G. L. ;Dunn, R. L.
- Publisher
- John Wiley and Sons
- Year
- 1998
- Tongue
- English
- Weight
- 367 KB
- Volume
- 42
- Category
- Article
- ISSN
- 0021-9304
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✦ Synopsis
Biodegradable barrier films were made by coagulating a solution of poly(DL-lactide) in N-methyl-2pyrrolidone on porous polyethylene pads wetted with saline solution. The semisolid films were cut into 10 × 10 mm barriers and implanted subcutaneously in rabbits. At monthly intervals, the polymer implant sites were compared histologically to those implanted with USP negative control plastic. The polymer films were retrieved from the surrounding tissue, dried, weighed, and the changes in molecular weight determined using gel permeation chromatography. The molecular weight of the polymer decreased at a relatively constant rate over 5 months; however, no significant mass loss occurred until 5 months postimplantation. Also, no distinct histological differences were noted between the polymer barrier and the control plastic sites until 6 months when histiocytes and multinucleated giant cells showed a modest increase around fragmented polymer films. Similar barrier films also were fitted over naturally occurring buccal dehiscence defects in beagle dogs and the tissue sites compared histologically at 6 months to sham-operated control sites. New bone and dense connective tissues closely approximated segments of the remaining polymer and demonstrated the biocompatibility of the biodegradable films. Histomorphometric analyses of treated sites compared to sham controls showed that the polymer barrier is effective in promoting bone and cementum regeneration in periodontal defects in dogs.