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Biodegradable Poly(ethylene carbonate) Nanoparticles as a Promising Drug Delivery System with “Stealth” Potential

✍ Scribed by Nadja Bege; Thomas Renette; Mirko Jansch; Regina Reul; Olivia Merkel; Holger Petersen; Catherine Curdy; Rainer H. Müller; Thomas Kissel

Publisher: John Wiley and Sons
Year: 2011
Tongue: English
Weight: 493 KB
Volume: 11
Category: Article
ISSN: 1616-5187
DOI: 10.1002/mabi.201000496

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✦ Synopsis

Abstract

The goal of this study was to investigate the suitability of poly(ethylene carbonate) (PEC) nanoparticles as a novel drug delivery system, fulfilling the requirements for a long circulation time. Particles were obtained with a narrow size distribution and nearly neutral zeta potential. Adsorption studies with human plasma proteins revealed that PEC nanoparticles bind much less proteins in comparison to polystyrene (PS) nanoparticles. Cell experiments with fluorescently labeled PEC showed no uptake of the nanoparticles by macrophages. These novel PEC nanospheres with their unique surface properties are a promising candidate for long circulating drug delivery systems in vivo.
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