Biodegradable Nanogels Prepared by Self-Assembly of Poly(L-lactide)-Grafted Dextran: Entrapment and Release of Proteins
✍ Scribed by Koji Nagahama; Tatsuro Ouchi; Yuichi Ohya
- Publisher
- John Wiley and Sons
- Year
- 2008
- Tongue
- English
- Weight
- 469 KB
- Volume
- 8
- Category
- Article
- ISSN
- 1616-5187
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✦ Synopsis
Abstract
We showed previously that poly(L‐lactide)‐grafted dextran could form biodegradable nanogels in water. In this paper, various properties of Dex__‐g‐PLLA nanogels were compared with Dex‐Chol (dextran‐cholesterol conjugate) nanogels to investigate the effects of hydrophobic units. Dex‐g‐PLLA nanogels exhibited significantly lower CAC and higher colloidal stability, indicating a strong tendency to form nanogels. We prepared lysozyme‐loaded Dex‐g‐PLLA nanogels, and they exhibited a sustained release of lysozyme for 1 week without denaturation in PBS at 37 °C. The Dex‐g‐__PLLA nanogels therefore have great potential as a delivery vehicle for therapeutic protein.
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