Biodegradable Heparin-Loaded Microspheres: Carrier Molecular Composition and Microsphere Structure

✍ Scribed by Xianglin Luo; Di Qiu; Bin He; Lijian Wang; Juan Luo

• Book ID: 102469907
• Publisher: John Wiley and Sons
• Year: 2006
• Tongue: English
• Weight: 283 KB
• Volume: 6
• Category: Article
• ISSN: 1616-5187
• DOI: 10.1002/mabi.200500236

✦ Synopsis

Abstract

Summary: Microspheres of amphiphilic triblock polymers PLLA‐PEG‐PLLA were investigated as carriers for heparin delivery. Two series of PLLA‐PEG‐PLLA triblock were synthesized and prepared into microspheres with heparin loaded. The microspheres were hollow and the surface morphology varied from smooth to porous. The pore size increased with increasing PEG content. The microsphere size distribution showed that higher PEG content increased the average microsphere size. The release rate of heparin was closely related to the surface morphology of the microspheres. DSC spectra showed that both cold crystalline temperature (T~c~) and crystalline melting temperature (T~m~) of heparin‐loaded microspheres were related to the copolymer composition and the T~c~ was lower than those of corresponding pure microspheres.
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