Biodegradable blend films based on two polysaccharide derivatives and their use as ibuprofen-releasing matrices
✍ Scribed by Ju-Zhen Yi; Li-Ming Zhang
- Book ID
- 101587832
- Publisher
- John Wiley and Sons
- Year
- 2006
- Tongue
- English
- Weight
- 146 KB
- Volume
- 103
- Category
- Article
- ISSN
- 0021-8995
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✦ Synopsis
Abstract
Differential scanning calorimetry (DSC), FTIR, X‐ray diffraction (XRD), and viscosity methods were used to examine the miscibility, interaction, and degradability of cationic guar gum (GG) and sodium carboxymethylcellulose (NaCMC) in their blend films. The experiment results prove that there exist electrostatic interactions and hydrogen bonding between GG and NaCMC. Blend films degrade quicker than pure GG or NaCMC film. Furthermore, the degradation rate of blend films is related to the interactions between GG and NaCMC. Based on the research of blend films as the drug carriers for Ibuprofen, it is found that the blend composition, initial drug concentration, and pH value affect the drug release and the GG/NaCMC blend films have good sustained release performance. © 2006 Wiley Periodicals, Inc. J Appl Polym Sci 103: 3553–3559, 2007