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Bioconjugates of curcumin display improved protection against glutathione depletion mediated oxidative stress in a dopaminergic neuronal cell line: Implications for Parkinson’s disease

✍ Scribed by G. Harish; C. Venkateshappa; Rajeswara Babu Mythri; Shiv Kumar Dubey; Krishna Mishra; Neetu Singh; Shireen Vali; M.M. Srinivas Bharath

Book ID: 108072803
Publisher: Elsevier Science
Year: 2010
Tongue: English
Weight: 383 KB
Volume: 18
Category: Article
ISSN: 0968-0896
DOI: 10.1016/j.bmc.2010.02.029

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## Abstract Glutathione (GSH) is an important endogenous antioxidant found in millimolar concentrations in the brain. GSH levels have been shown to decrease with aging. Alzheimer's disease (AD) is a neurodegenerative disorder associated with aging and oxidative stress. Aβ(1–42) has been shown to in