Biocompatible superparamagnetic iron oxide nanoparticle dispersions stabilized with poly(ethylene glycol)–oligo(aspartic acid) hybrids
✍ Scribed by Shourong Wan; Junsheng Huang; Miao Guo; Hongkai Zhang; Youjia Cao; Husheng Yan; Keliang Liu
- Book ID
- 102873285
- Publisher
- John Wiley and Sons
- Year
- 2007
- Tongue
- English
- Weight
- 539 KB
- Volume
- 80A
- Category
- Article
- ISSN
- 1549-3296
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✦ Synopsis
Abstract
Methoxypoly(ethylene glycol)–oligo(aspartic acid) (MPEG–Asp~n~‐NH~2~, n = 2–5) hybrid block copolymers were synthesized and used as stabilizers to prepare superparamagnetic Fe~3~O~4~ nanoparticles with magnetite as the inner core and and poly(ethylene glycol) as the hydrophilic outer shell. The aqueous dispersions of the nanoparticles were stable at pH 2–11 and in 1__M__ NaCl solution, when repeat number, n, was 3 or more. Transmission electron microscopy showed that the nanoparticles, stabilized with MPEG–Asp~3~‐NH~2~, were about 14 nm in diameter. Magnetic measurements indicated that MPEG–Asp~3~‐NH~2~‐coated iron oxide nanoparticles showed superparamagnetic behavior. Cell adhesion assay and in vitro cell viability/cytotoxicity studies showed that MPEG–Asp~3~‐NH~2~‐coated iron oxide nanoparticles had less effect on cell adhesion/viability and morphology, and less cytotoxicity compared with uncoated, poly (acrylic acid)‐coated, and MPEG–poly(acrylic acid)‐coated iron oxide nanoparticles. © 2006 Wiley Periodicals, Inc. J Biomed Mater Res, 2006