Biocompatibility of biodegradable and nonbiodegradable polymer-coated stents implanted in porcine peripheral arteries

✍ Scribed by Ivan K. Scheerder; Krzysztof L. Wilczek; Eric V. Verbeken; Joke Vandorpe; Pham N. Lan; Etienne Schacht; Jan Piessens; Hilaire Geest

• Publisher: Springer
• Year: 1995
• Tongue: English
• Weight: 698 KB
• Volume: 18
• Category: Article
• ISSN: 1432-086X
• DOI: 10.1007/bf00239417

✦ Synopsis

Purpose:

To investigate the neointimal response to poly(organo)phosphazene- and amphiphilic polyurethane-coated, oversized, stainless steel stents implanted in porcine peripheral arteries.

Methods:

Nonarticulated, stainless steel, slotted-tube stents were coated with 1) a biodegradable poly-(organo)phosphazene with aminoacid ester side groups and 2) a biostable polyurethane prepared from an amphiphilic polyether, diphenyl methane-4,4'-diisocyanate and butane diol as chain extender. the stents were deployed in porcine peripheral arteries using an oversized balloon.

Results:

The neonintimal response to amphiphilic polyurethane-coated stents was similar to the uncoated metallic stents. poly(organo)phosphazene-coated stents, however, induced a severe histiolymphocytic and fibromuscular reaction resembling a foreign body reaction.

Conclusions:

Amphiphilic polyurethane is very promising as a biocompatible stent coating. poly-(organo)phosphazene, however, appears unsuitable for this purpose.