Microencapsulation of islets of Langerhans has been proposed as a means of preventing their immune destruction following transplantation. Microcapsules of diameters <350 m made with an electrostatic pulse system present many advantages relative to standard microcapsules (700-1500 m), including small
Biocompatibility of alginate–poly-l-lysine microcapsules for cell therapy
✍ Scribed by Gorka Orive; Susan K. Tam; José Luis Pedraz; Jean-Pierre Hallé
- Book ID
- 108069677
- Publisher
- Elsevier Science
- Year
- 2006
- Tongue
- English
- Weight
- 499 KB
- Volume
- 27
- Category
- Article
- ISSN
- 0142-9612
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## Abstract Alginate/poly‐L‐lysine(PLL)/alginate capsules are used widely for the microencapsulation of cells. Alginate consists of guluronic acid and mannuronic acid, the ratio and sequence of which affect the properties of the alginate. Using C5‐epimerases, mannuronic acid can be converted to gul
Transplantation of microencapsulated islets of Langerhans is impaired by a pericapsular host reaction that eventually induces graft failure. We are studying the role of cytokines in the pathogenesis of this reaction, using the model of alginate-polylysine microcapsule implantation in rat epididymal