Determination of the kinetics of water-soluble degradation products inside poly(lactide-co-glycolide) (PLGA) delivery systems during polymer degradation is important to evaluate the polymer microclimate conditions, particularly microclimate pH changes for optimization of encapsulated drug stability.
Biochemical synthesis of water soluble polyanilines: Poly(p-aminobenzoic acid)
β Scribed by K. Shridhara Alva; Kenneth A. Marx; Jayant Kumar; Sukant K. Tripathy
- Publisher
- John Wiley and Sons
- Year
- 1996
- Tongue
- English
- Weight
- 262 KB
- Volume
- 17
- Category
- Article
- ISSN
- 1022-1336
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β¦ Synopsis
Abstract
This report describes the synthesis of a water soluble polyaniline through a biochemical synthetic route. The oxidative free radical coupling mechanism for the synthesis of poly(pβaminobenzoic acid) is catalyzed by horseradish peroxidase in the presence of hydrogen peroxide. The resulting polymer is electrochemically active and undergoes reversible redox reactions. The polymer as synthesized is self doped and undergoes undoping in alkaline or ammonia solutions.
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