Biochemical polymorphism of the HLA-DP heavy chain

✍ Scribed by Vincent Lotteau; Luc Teyton; Marie-Marthe Tongio; Annie Soulier; Mögens Thomsen; Maryline Sasportes; Dominique Charron

• Book ID: 104755373
• Publisher: Springer-Verlag
• Year: 1987
• Tongue: English
• Weight: 471 KB
• Volume: 25
• Category: Article
• ISSN: 0093-7711
• DOI: 10.1007/bf00396107

✦ Synopsis

The human major histocompatibility complex class II antigens are encoded within the HLA-D region. This genetic region is composed of at least three subregions, HLA-DR, -DQ, -DP, each encoding one or several c~ and/3 chain loci. Additional loci (DZ and DO) have been identified for which no protein has yet been characterized (reviewed by Bell et al. 1985 andKorman et al. 1985). While DR and DQ specificities can be defined serologically, no alloantiserum recognizing DP specificities is presently available and HLA-DP phenotyping relies on cellular techniques (Shaw et at. 1981, Pawelec et at. 1982). Until now at least seven DP specificities have been defined. The DP subregion has been shown to contain four genes (Servenius et at. 1984, Auffray et al. 1984, Korman et al. 1985). While DP~ and DP¢ genes are expressed, there is some evidence that SX~ and SX~ genes are not (Servenius et al. 1984, Okada et at.