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Biochemical modulation of fluorouracil: comparison of methotrexate, folinic acid, and fluorouracil versus folinic acid and fluorouracil in advanced colorectal cancer: a randomized trial

✍ Scribed by A. Polyzos, N. Tsavaris, A. Giannopoulos…

Book ID
120776659
Publisher
Springer
Year
1996
Tongue
English
Weight
91 KB
Volume
38
Category
Article
ISSN
0344-5704

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Background. Metastatic colorectal cancer is generally incurable. The most active regimen available, 5-fluorouracil(5-FU) and folinic acid (Leucovorin), produces response rates of approximately 25% to 30%. Methyl-lomustine is a nitrosourea with modest activity against colorectal cancer. A randomized