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Biochemical mechanism of insulin sensitization, lipid modulation and anti-atherogenic potential of PPAR α/γ dual agonist: Ragaglitazar

✍ Scribed by Sudhir Sharma; Angaru Sowjanya; Manju Kumari; Raichur Suryaprakash; Gershome Cynthia; Juluri Suresh; Ranjan Chakrabarti

Book ID
116718848
Publisher
Elsevier Science
Year
2006
Tongue
English
Weight
622 KB
Volume
80
Category
Article
ISSN
0024-3205

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[14C] and [3H]-labelling of Ragaglitazar
[14C] and [3H]-labelling of Ragaglitazar: A dual acting PPARα and PPARγ agonist with hypolipidemic and anti-diabetic activity
✍ Jesper B. Kristensen; Steen K. Johansen; Jacob S. Valsborg; Lars Martiny; Christ 📂 Article 📅 2003 🏛 John Wiley and Sons 🌐 French ⚖ 138 KB

## Abstract Currently, Ragaglitazar is being developed as a drug for the treatment of hyperglycaemia and hyperlipidemia in patients with type 2 diabetes. Here, we report the labelling of Ragaglitazar with carbon‐14 and tritium for in vivo and in vitro investigations. Two different carbon‐14 labelle