Biochemical indicators of vitamin A depletion in children with cholestasis

✍ Scribed by Dr. Olivier Amédée-Manesme; Harold C. Furr; Fernando Alvarez; Michelle Hadchouel; Daniel Alagille; James Allen Olson

• Publisher: John Wiley and Sons
• Year: 1985
• Tongue: English
• Weight: 547 KB
• Volume: 5
• Category: Article
• ISSN: 0270-9139
• DOI: 10.1002/hep.1840050614

✦ Synopsis

Biochemical indicators of vitamin

A status were measured in 24 children (1 month to 6 years old) with severe cholestasis starting early in Iife and in 21 children (3 months to 13 years old) with liver disease but without cholestasis. Liver vitamin A concentrations, expreseed as micrograms of retinol per gram of liver (mean 2 S.D.), were 6.3 f 7.1 (range: 0.14 to 28) and 143 2 108 (range: 18 to 424), respectively, in cholestatic and noncholestatic children. In infanta <6 months of age, liver vitamin A values < l o pg per gm were found in 14 of 17 cholestatic children but in none of 3 noncholestatic subjects. Plasma vitamin A values, expreeeed as micrograms of retinol per deciliter (mean f S.D.), were 23 f 18 (range: 3 to 62) and 46 f 33 (range: 14 to 125), respectively, for the two groups. Plasma retinol values < l o pg per dl were always aesociated with liver concentrations