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Biochemical fingerprints of prion diseases: scrapie prion protein in human prion diseases that share prion genotype and type

✍ Scribed by Tao Pan; Ruliang Li; Shin-Chung Kang; Manuela Pastore; Boon-Seng Wong; James Ironside; Pierluigi Gambetti; Man-Sun Sy

Book ID
111178631
Publisher
John Wiley and Sons
Year
2005
Tongue
English
Weight
385 KB
Volume
92
Category
Article
ISSN
0022-3042

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## Abstract Scrapie is a transmissible spongiform encephalopathy affecting the central nervous system in sheep. The key event in such neurodegeneration is the conversion of the normal prion protein (PrP^C^) into the pathological isoform (PrP^Sc^). Misfolded prion proteins are normally degraded by t