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Biochemical findings in multiple sclerosis

✍ Scribed by F. Gosseye-Lissoir; P. Delmotte; H. Carton

Publisher
Springer
Year
1977
Tongue
English
Weight
494 KB
Volume
216
Category
Article
ISSN
0340-5354

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✦ Synopsis

Lymphocyte stimulation tests with human basic protein of myelin were performed on patients with multiple sclerosis, with other neurological diseases and on normal subjects. In both MS and OND group, a hypersensitization to basic protein was seen in about one third of the cases. All normal subjects, except one, had negative responses. In the MS group, a positive correlation could be found with some features of the disease: significantly more positive responses were found in independent patients with a short duration of illness and in those with an oligoclonal distribution in the CSF. The authors compare their results with those of the literature. The possible role of BP in pathogeny of MS and OND is discussed.

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