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Biochemical features of pseudomembrane at the bone-cement interface of loosened total hip prostheses

✍ Scribed by Shoji, Hiromu ;Karube, Shunji ;D'ambrosia, Robert D. ;Dabezies, Eugene J. ;Miller, Douglas R.

Publisher: John Wiley and Sons
Year: 1983
Tongue: English
Weight: 623 KB
Volume: 17
Category: Article
ISSN: 0021-9304
DOI: 10.1002/jbm.820170411

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✦ Synopsis

Biochemical features of pseudomembrane formed at the bone-cement interface of 13 failed total hip replacements were studied and histological examination of the pseudomembrane was conducted. The results of biochemical analyses revealed on average hydroxyproline, 86 pg/mg; water content, 57%; hexosamine, 12 pg/mg; glucosamine/ galactosamine, 1.4%; and calcium, 2.1%. Approximately 78% of collagen was extracted with pepsin, whereas only 8 and 0.3% collagen were extracted with acetic acid and neutral salt, respectively. On further differential salting out of the extracted collagen, about 77% was type I collagen, 19% type 111, and 2.6% type V. Unlike pseudoarthrosis of fracture, no type I1 collagen was identified. Overall biochemical features in the light of the histological appearance suggested that pseudomembrane resembles granulation tissue. Bone healing mechanisms at the bone-cement interface appear to differ from that of fracture healing.

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