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Biochemical Evidence for Orphanin FQ/Nociceptin Receptor Heterogeneity in Mouse Brain

✍ Scribed by John P. Mathis; Jennifer Ryan-Moro; Albert Chang; Judith S.H. Hom; David A. Scheinberg; Gavril W. Pasternak


Book ID
115579569
Publisher
Elsevier Science
Year
1997
Tongue
English
Weight
99 KB
Volume
230
Category
Article
ISSN
0006-291X

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The presence of pairs of basic amino acids within the orphanin FQ/Nociceptin (OFQ/N) sequence has raised the possibility that truncated versions of the peptide might be physiologically important. OFQ/N(1-11) is pharmacologically active in mice, despite its poor affinity in binding assays (K i ΟΎ 250