Biochemical Engineering of Natural Product Biosynthesis Pathways
β Scribed by William R. Strohl
- Publisher
- Elsevier Science
- Year
- 2001
- Tongue
- English
- Weight
- 209 KB
- Volume
- 3
- Category
- Article
- ISSN
- 1096-7176
No coin nor oath required. For personal study only.
β¦ Synopsis
Metabolic engineering of natural products is a science that has been built on the goals of traditional strain improvement with the availability of modern molecular biological technologies. In the past 15 years, the state of the art in metabolic engineering of natural products has advanced from the first proof-of-principle experiment based on minimal known genetics to a commonplace event using highly specific and sophisticated gene manipulation methods. With the availability of genes, host organisms, vector systems, and standard molecular biological tools, it is expected that metabolic engineering will be translated into industrial reality.
π SIMILAR VOLUMES
## Abstract Feeding experiments using isotopically labeled precursors remain crucial elements in the study of natural product biosynthesis. Through careful isotope tracer studies, a number of previously unrecognized biosynthetic pathways have now become obvious. One of the remarkable examples is th
The structural and catalytic similarities between modular nonribosomal peptide synthetase (NRPS) and polyketide synthase (PKS) inspired us to search for hybrid NRPS-PKS systems. By examining the biochemical and genetic data known to date for the biosynthesis of hybrid peptide-polyketide natural prod