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Biochemical consequences of 5-fluorouracil gastrointestinal toxicity in rats; effect of high-dose uridine

✍ Scribed by J. Kralovanszky; N. Prajda; S. Kerpel-Fronius; T. Bagrij; E. Kiss; G. J. Peters


Publisher
Springer
Year
1993
Tongue
English
Weight
630 KB
Volume
32
Category
Article
ISSN
0344-5704

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The effect of allopurinol pretreatment on the toxicity of 5-tluorouracil(5-FU) was examined in a clinical trial. Twenty-three patients were given bolus infusions of 5-FU every two weeks in doses that produced mild toxicity (0.8-1 .9 g/m'). O n alternate courses patients were pretreated with allopuri