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Biochemical characterization of prostasin, a channel activating protease

✍ Scribed by Aaron Shipway; Henry Danahay; Jennifer A. Williams; David C. Tully; Bradley J. Backes; Jennifer L. Harris


Book ID
116289268
Publisher
Elsevier Science
Year
2004
Tongue
English
Weight
1018 KB
Volume
324
Category
Article
ISSN
0006-291X

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## Abstract Prostasin (CAP1/PRSS8) is a glycosylphosphatidylinositol‐anchored membrane serine protease believed to be critical for the regulation of epithelial sodium channel (ENaC) activity. Prostasin is synthesized as an inactive zymogen that requires a site‐specific endoproteolytic cleavage to b