Biochemical aspects of the mechanism of action of antiarrhythmic drugs on mitochondria. VII. Effect on energy-linked reactions and on membrane potential
✍ Scribed by Maria Lúcia Wambier Klüppel; Hélcio Resende Borba; Orieta Silveira; Luiz Carlos Vieira Lopes; Annibal De Paiva Campello
- Publisher
- John Wiley and Sons
- Year
- 1986
- Tongue
- English
- Weight
- 506 KB
- Volume
- 4
- Category
- Article
- ISSN
- 0263-6484
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✦ Synopsis
Effects of the antiarrhythmic drugs (propranolol, perhexiline maleate, lidoflazine and iproveratril) on energy-linked reactions and on membrane potential were studied. Propranolol, perhexiline maleate and Iidoflazine inhibit the ATPase activity of undamaged and broken mitochondria, and of submitochondriai particles. All drugs are inhibitors of either ATP-driven or of succinate-driven reduction of NADP+. The antiarrhythmics promote a decrease in the membrane potential upon energization of the mitochondrial membrane by a-ketoglutarate, succinate, or ATP. It was suggested that these drugs have a primary action on the mitochondrial membrane, thus altering the activities of membrane proteins (channels and enzymes).