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Biochemical and pharmacological studies with 1-β-d-arabinofuranosylcytosine in man

✍ Scribed by William A. Creasey; Rose J. Papac; Maria E. Markiw; Paul Calabresi; Arnold D. Welch


Book ID
115769213
Publisher
Elsevier Science
Year
1966
Tongue
English
Weight
894 KB
Volume
15
Category
Article
ISSN
0006-2952

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✍ Howell, Stephen B. ;Streifel, Jerome A. ;Pfeifle, Craig E. 📂 Article 📅 1982 🏛 John Wiley and Sons 🌐 English ⚖ 592 KB

The effect of thymidine (dThd) and hydroxyurea (HU) on the cellular metabolism of 1 -P-D-arabinofuranosylcytosine (Ara-C) was investigated in the human promyelocytic cell line HL-60. Both dThd and HU increased the cellular uptake and rate of formation of Ara-CTP. Measurement of ribo-and deoxyribonuc