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Biochemical and pharmacological properties of BW 1370U87 — a novel, selective monoamine oxidase A inhibitor

✍ Scribed by White, H.L; Beek, O; Rigdon, G; Kraemer, G.W; Cooper, B.R


Book ID
122027090
Publisher
Elsevier Science
Year
1991
Tongue
English
Weight
225 KB
Volume
1
Category
Article
ISSN
0924-977X

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## 2614W94 [3-(1-trifluoromethyl) ethoxyphenoxathiin 10,10-dioxide] is a selective, reversible inhibitor of monoamine oxidase-A with a competitive mechanism of inhibition and a K i value of 1.6 nM with serotonin as substrate. In pretreated rats, the ED 50 value after single oral dosing was 1.7 mg/